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  Seroprevalencia de infecciones por el virus del Nilo Occidental en la población general del sur de España

  Enfermedades Infecciosas y Microbiología Clínica 2007;25(9): 561-565

  

  BERNABEU-WITTEL M, RUIZ-PÉREZ M, DEL TORO MD, AZNAR J, MUNIAIN Á, DE ORY F, PACHÓN J, DOMINGO C

  Enfermedades Infecciosas y Microbiología Clínica 2007;25(9): 561-565

  Tipo artículo:

  Resumen del Autor: <FONT FACE="Univers 65 Bold" SIZE=2>Objective. To analyze the prevalence of past and recent infections by West Nile virus (WNV) and the risk factors associated with WNV exposure in a representative population from southern Spain. <FONT FACE="Univers 65 Bold" SIZE=2>Methods. Sample size was established for an estimated prevalence of past WNV infections of 5 6 <FONT FACE="Univers 65 Bold">2.5% in 504 subjects. A pre-stratification was performed according to age distribution and place of residence. After random telephone solicitation and acquisition of informed consent, a serum sample was collected and an epidemiologic survey performed on all participating subjects. Samples were tested with ELISA-IgG and MAC-ELISA to detect specific IgG and IgM antibodies; results were confirmed by the plaque reduction neutralization test (PRNT). Multivariate analysis using a forward stepwise logistic regression model was performed to assess potential risk factors associated with WNV exposure. <FONT FACE="Univers 65 Bold" SIZE=2>Results. Prevalence of past WNV infections confirmed by PRNT in the 504 participants was 0.6%, affecting mainly older persons (mean age 65 6 <FONT FACE="Univers 65 Bold">23<FONT FACE="Univers 65 BoldOblique"> vs.<FONT FACE="Univers 65 Bold"> 34 6 <FONT FACE="Univers 65 Bold">22 years;<FONT FACE="Univers 65 BoldOblique"> P 5 <FONT FACE="Univers 65 Bold">0.018), those living in rural areas (5.4%<FONT FACE="Univers 65 BoldOblique"> vs.<FONT FACE="Univers 65 Bold"> 0% in urban areas;<FONT FACE="Univers 65 BoldOblique"> P 5 <FONT FACE="Univers 65 Bold">0.01), and individuals with risk professions (prevalence 2.8%<FONT FACE="Univers 65 BoldOblique"> vs.<FONT FACE="Univers 65 Bold"> 0%;<FONT FACE="Univers 65 BoldOblique"> P 5 <FONT FACE="Univers 65 Bold">0.048). None of the five recent infections detected by MAC-ELISA was confirmed by PRNT. <FONT FACE="Univers 65 Bold" SIZE=2>Conclusions. These results strongly suggest past circulation and exposure of the human population to WNV in southern Spain. Traducir

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  ID MEDES: 36762

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