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    Streptococcus pneumoniae virulence factors and their clinical impact: an update

    Enfermedades Infecciosas y Microbiología Clínica 2006;24(8): 512-517

    medes_medicina en español

    DEL MAR GARCÍA-SUÁREZ M, MÉNDEZ FJ, VÁZQUEZ DE LA IGLESIA F

    Enfermedades Infecciosas y Microbiología Clínica 2006;24(8): 512-517

    Tipo artículo:

    Resumen del Autor: <FONT FACE="Univers 65 Bold" SIZE=2>The morbidity and mortality rates associated with<FONT FACE="Univers 65 BoldOblique" SIZE=2> Streptococcus pneumoniae<FONT FACE="Univers 65 Bold" SIZE=2> remain very high worldwide. The virulence of this bacterium is largely dependent on its polysaccharide capsule, which is quite heterogeneous and represents a serious obstacle for designing effective vaccines. However, it has been demonstrated that numerous protein virulence factors are involved in the pathogenesis of pneumococcal disease. An important related finding from experimental animal models is that non-capsulated strains of pneumococci are protective against capsulated ones. Hence, new vaccine designs are focused on the surface proteins (e. g., PspA and PspC) and on the cytolysin, pneumolysin. Moreover, several virulence factors have potential value for pneumococcal diagnosis by urinalysis. In this paper, we review the virulence factors involved in bacteria-host interactions, and the new developments in vaccines and diagnostic methods.

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    ID MEDES: 32433



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